Beilstein J. Org. Chem.2017,13, 2631–2636, doi:10.3762/bjoc.13.261
in only five steps from the cheap starting material N-acetylglucosamine. This efficient synthesis should enable future studies into the importance of 1,6-anhydromuramic acid in bacterialcellwallrecycling processes.
Keywords: N-acetylmuramic acid; anhydrosugars; antibiotic resistance; bacterial
cellwallrecycling; carbohydrate synthesis; Introduction
1,6-Anhydro-N-acetylmuramic acid (AnhydroMurNAc, 1, Figure 1) and its derivatives (e.g., 2 and 3) are of great interest due to their integral role in bacterialcellwallrecycling [1][2] and the induction of antibacterial resistance [3